EKSPRESI BMP-2 PADA PEMBERIAN HYDROXIAPATITE XENOGRAFT DAN HYDROXIAPATITE TOOTH-DERIVED BONE GRAFT MATERIAL PADA SOKET MARMUT
Keywords:
BMP-2, hydroxyapatite toothgraft, hydroxyapatite xenograftAbstract
Latar Belakang: hydroxyapatite telah menujukkan kemampuan untuk memicu regenerasi tulang pada
fungsinya sebagai scaffold sekaligus sebagai pembawa BMP-2 lokal. Hydroxyapatite toothgraft memiliki rasio
Ca/P lebih tinggi dibanding hydroxyapatite xenograft sehingga lebih banyak jumlah BMP-2 yang dapat
diserap. Tujuan: untuk membandingkan jumlah ekspresi BMP-2 antara hydroxyapatite toothgraft dengan
hydroxyapatite xenograft. Metode: sebanyak 33 ekor marmut jantan dilakukan ekstraksi pada gigi insisif
mandibula kiri, kemudian dibagi dalam tiga grup. Grup A (n=11): soket post ekstraksi diisi dengan
hydroxyapatite xenograft, grup B (n=11): soket post ekstraksi diisi dengan hydroxyapatite toothgraft, dan
grup C (n =11): soket post ekstraksi tidak diisi bahan graft. Setelah 14 hari marmut dikorbankan kemudian
sample dianalisis menggunakan kit IHC. Hasil: Data dianalisis menggunakan Krukal-Wallis test untuk
membandingkan masing-masing grup (α = 0,05). Mean ekspresi BMP-2 pada hydroxyapatite xenograft
adalah 15,73±2.649, pada hydroxyapatite toothgraft adalah 23,55±3.236, dan pada grup kontrol adalah 9,
18 ±2,272. Kesimpulan: ekspresi BMP-2 pada hydroxyapatite toothgraft lebih banyak dibanding
hydroxyapatite xenograft.
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