PENGARUH LENDIR BEKICOT (Achatina fulica) TERHADAP JUMLAH FIBROBLAS PADA SOKET

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Published: Dec 15, 2020
DOI: https://doi.org/10.21776/ub.eprodenta.2020.004.02.1
Keywords:
Lendir Bekicot (Achatina fulica), sel fibroblast, penyembuhan

Main Article Content

Fredy Mardiyantoro
Brawijaya University
Zefry Zainal Abidin
Astika Swastirani
Handaru Dibya

Abstract

Latar belakang : Penyembuhan luka adalah proses dinamis yang menghasilkan serangkaian aktivitas termasuk peradangan, proliferasi, dan migrasi sel-sel fibroblast ke daerah luka. Fibroblas sangat penting dalam mendukung penyembuhan luka normal, dari fase akhir inflamasi hingga fase akhir epitelisasi pada jaringan yang mengalami jejas. Tujuan : Penelitian ini mengamati pengaruh lendir bekicot (Achatina fulica) dalam mempercepat proses penyembuhan melalui proliferasi fibroblas di soket paska pencabutan gigi. Metode : Tikus wistar (Rattus novergicus) dibagi menjadi dua kelompok, dan gigi insisivus pertama rahang bawah kiri mereka dicabut. Soket bekas pencabutan diberikan lendir bekicot pada kelompok perlakuan dan kelompok kontrol tidak diberikan lendir bekicot. Pada hari ke 3, 5 dan 7, tikus dilakukan eutanasia dan sampel jaringan diolah untuk analisis histologi. Hasil : Uji statistik penelitian menunjukkan bahwa lendir bekicot (Achatina fulica) secara signifikan meningkatkan jumlah sel fibroblas pada kelompok perlakuan dibandingkan dengan kelompok kontrol (p<0,05). Kesimpulan : Dari penelitian ini dapat disimpulkan bahwa lendir siput (Achatina fulica) mempunyai potensi yang cukup baik dalam merangsang proses penyembuhan luka setelah pencabutan gigi.

Article Details

Issue
Vol. 4 No. 2 (2020)
Section
Articles

E-Prodenta Journal of Dentistry receives original texts that have not been published in any media in any language, or are being sent to other journals at the same time. If the manuscript has already been presented in a particular symposium or seminar, then it should be written in the description. The submission of the manuscript shall be accompanied by a statement of authenticity of writing and unpublished statements made and signed by the first author. When the manuscript is accepted for publication, the authors agree to automatic transfer of the copyright to the publisher. 

Author Biography

Fredy Mardiyantoro, Brawijaya University

Oral and Maxillofacial Departement

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